Mechanisms for increasing synthesis of P-selectin are suggested by its presence on the apical surface of endothelial cells in human tissues with chronic or allergic inflammation.16-18 Indeed, TNF-α, IL-1β, or LPS increases expression of P-selectin mRNA and protein in murine endothelial cells in vitro and in vivo.10,19,20 Transient activation of the murine P-selectin gene requires the cooperative binding of NF-κB, ATF-2, and other transcription factors.21 However, the binding sites for NF

P-selectin was constitutively expressed at low levels on the surface of passage 1 HUVEC. Exogenous administration of thrombin resulted in a marked and rapid, dose-dependent increase in the surface P-selectin expression within 10 min of stimulation (Fig. 1,A and B).

Synonyme: GRMP, CD62, LECAM3, PSEL, Selektin P, CD62P, GMP140 Englisch: P-selectin, selectin P P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene.P-selectin functions as a cell adhesion molecule (CAM) on the Selectin P ligand, also known as SELPLG or CD162 (cluster of differentiation 162 ), is a human gene. SELPLG codes for PSGL-1, the high affinity For transfection of specific primary cells, e.g. mouse macrophages, in the 4D- Nucleofector™ X Unit (20 µL format). Plasma Selectin (P-selectin), also known CD62P and GMP-140, is a cell adhesion molecule and a member of the Selectin family. It is found in granules in P-Selectin. P-selektin. Engelsk definition.

P selectin

Gr_32µg/ml P-selectin. ICAM-1. VCAM-1. PECAM-1. Naive HUVEC + Exposed U937. P-selectin binder till P-selectin glycoprotein ligand 1 PSGL-1 på monocyten, andra leukocyter och endotel.Leder till adhesion av trombocyten till leukocyt och RCP9130, Prolactin, 1 mg. RCP9248, P-selectin (western blot control), 10 μg.

Där fungerar proteinet som receptor för neutrofila granulocyter. Lösligt P-selectin är en aktiveringsmarkör för trombocyter.

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RCP9116, P-selectin Abnormal P-selectin localization during megakaryocyte development determines thrombosis in the gata1low model of myelofibrosis. Article. Oct 2013; Platelets.

P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type 1 transmembrane glycoprotein, and is one of the most commonly studied proteins that regulate cell rolling. P-selectin is stored in the Weibel-Palade bodies of endothelial cells, as well as in a-granules of platelets.

[PubMed:7585950] Wilkins PP, Moore KL, McEver RP, Cummings RD: Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectin. P selectin,leukocyte adhesion molecule,granule membrane protein (platelet,endothelium),induced by thrombin,histamine,peroxides from platelet alpha granule,high expressed in atherosclerotic plaques SELP Mechanisms for increasing synthesis of P-selectin are suggested by its presence on the apical surface of endothelial cells in human tissues with chronic or allergic inflammation.16-18 Indeed, TNF-α, IL-1β, or LPS increases expression of P-selectin mRNA and protein in murine endothelial cells in vitro and in vivo.10,19,20 Transient activation of the murine P-selectin gene requires the cooperative binding of NF-κB, ATF-2, and other transcription factors.21 However, the binding sites for NF Search results for p selectin at Sigma-Aldrich. Summary: This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. P-selectin, also called GMP-140, CD62, or selectin P, is a 140-kD adhesion molecule, expressed at the surface of activated cells, that mediates the interaction of activated endothelial cells or platelets with leukocytes. SELP / P-Selectin / CD62P selectin P (granule membrane protein 140kDa, antigen CD62) SELP encodes a 140 kD protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells.

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The Potential of the Quick Detection of Selectins Using Raman Spectroscopy to Discriminate Lung Cancer Patients from Healthy Subjects 2017-11-06 · P-selectin is one of the first cell surface molecules to be expressed on the endothelial cell in response to inflammatory stimuli, and triggers initial neutrophil rolling along the microvascular endothelium (1,10,23,25,31,38,46). Its expression on the endothelial cell lumenal P-Selectin (also called GMP-140) expressed on activated platelets and endothelial cells. Selectins interact with specific carbohydrates expressed by activated endothelial cells, monocytes, and neutrophils. In this video we discuss the three different types of selectins and their involvement in the immune system.

2019-12-01 Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.
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P-selectin belongs to the family of selectin adhesion molecules, and is expressed by platelets and endothelial cells on stimulation. This pattern of expression

title = "P-Selectin and P-Selectin Glycoprotein Ligand 1 Mediate Rolling of Activated CD8+ T Cells in Inflamed Colonic Venules.",. abstract = "BACKGROUND:: Detect Mouse P Selectin/SELP with <5pg/ml sensitivity. Format: 96-well plate with removable strips.

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Search results for p-selectin at Sigma-Aldrich. Summary: This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes.

P-selectin exponeras och kan binda till PSGL-1 (p-selectin glycoproteinligand 1) på monocyter, leukocyter och endotelceller. Detta gör att trombocyten kan fästa av J Grossman — samma sätt betydelsen av P-selectin-glykoproteinligand-1 (PSGL-1) och antikroppar mot denna ytmolekyl förhindrade adhesionen av A. phagocytophilum till (CK-MB); Flödescytometri-analys av VASP-P; ELISA-bestämningar av ET-1 och vWF; P-selectin- och cAMP-bestämningar; Inflammatoriska medlarnivåer Chai CM, Almen T, Aspelin P, Baath L. Effects on erythrocyte aggregation and Thorlacius H. CC chemokines induce P-selectin-dependent neutrophil rolling LPS gör dock inte att trombocyter aggregeras eller att trombocyter uttrycker sin normala aktiveringsmarkör P-selectin (vilket har gjort att forskargrupper trott att as IL-4, IL-6, IL-8, and IL-13 from human mast cells/basophils, as well as inhibition of the expression of the adhesion molecule P-selectin on endothelial cells. as well as inhibition of the expression of the adhesion molecule P-selectin on endothelial cells. Dessa omfattar hämning av frisättning av proinflammatoriska P-selectin on endothelial cells.